Peptide Hydrolysates from Astragalus membranaceus Bunge Inhibit the Expression of Matrix Metalloproteinases in Human Dermal Fibroblasts
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چکیده
منابع مشابه
Astragalus membranaceus
Astragalus L., is one of the largest genus of flowering plants in the Leguminosae family. The aim of this study was to review anti-carcinoma activities of this valuable herb. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 128 references. In this study, 113 studies was accepted fo...
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To investigate the pathophysiological role of fibroblasts in tissue metabolism, we analysed gelatin-degrading enzymes secreted from skin cells in culture. Using a gelatin-zymography method, matrix metalloproteinase (MMP)-2 was constitutively secreted from fibroblasts, whereas both MMP-2 and MMP-9 were secreted from keratinocytes. MMP-9 expression by fibroblasts was induced by the addition of tr...
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BACKGROUND Cyclosporin A (CsA), an immunosuppressive agent modifies the wound healing process through an influence on extracellular matrix metabolism. We have compared the effects of CsA on dermal fibroblasts from nude (FOXN1 deficient) mice, a genetic model of skin scarless healing, and from control (C57BL/6 J (B6) mice to evaluate metabolic pathways that appear to have important roles in the ...
متن کاملExtract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
BACKGROUND Astragalus membranaceus (AM) is a commonly used herb in traditional Chinese medicine (TCM), which has been used as an essential tonic to treat various diseases for more than 2000 years. In this study, we aimed to investigate the biological effects of extract from AM on breast cancer cell and its mechanism. METHODS To prepare the extract, dried AM were ground and extracted with wate...
متن کاملTwo new cycloartane saponins from the roots of Astragalus membranaceus.
Two new cycloartane-type triterpenoid saponins were isolated from the roots of Astragalus membranaceus (FISCH.) BGE. (Leguminosae) cultivated in Kangwon province, Korea. These saponins were named astramembranosides A and B and were established to be cycloastragenol 6,25-di-O-beta-D-glucopyranoside (astramembranoside A) and cyclocanthogenin 3-O-beta-D-glucopyranosyl(1-->2)-beta-D-xylopyranoside ...
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ژورنال
عنوان ژورنال: KSBB Journal
سال: 2014
ISSN: 1225-7117
DOI: 10.7841/ksbbj.2014.29.5.380